Cutaneous lesions of dermatomyositis are improved by hydroxychloroquine
Identifieur interne : 003607 ( Main/Exploration ); précédent : 003606; suivant : 003608Cutaneous lesions of dermatomyositis are improved by hydroxychloroquine
Auteurs : Thomas Y. Woo [États-Unis] ; Jeffrey P. Callen [États-Unis] ; John J. Voorhees [États-Unis] ; David R. Bickers ; Ruth Hanno [États-Unis] ; Curtis HawkinsSource :
- Journal of the American Academy of Dermatology [ 0190-9622 ] ; 1984.
English descriptors
- Teeft :
- Acrodermatitis enteropathica, American academyof dermatology, Antibody level, Antimalarial, Arch dermatol, Arthralgia, Barium enema, Bibasilar rales, Biopsy, Black woman, Chest examination, Corticosteroid, Creatinine clearance, Cutaneous, Cutaneous disease, Cutaneous lesions, Cuticular overgrowth, Dermatologic evaluation, Dermatology, Dermatomyositis, Direct immunofluorescent biopsy, Dorsal surfaces, Erythema, Facial erythema, Heliotrope, Homogeneous pattern, Hydroxychloroquine, Insertional irritability, Intravenous pyelogram, Joint symptoms, Laboratory evaluation, Lesion, Mayo clinic, Methotrexate, Muscle biopsy, Muscle disease, Muscle enzymes, Muscle strength, Muscle weakness, Myositis, Normal limits, Olmsted syndrome, Open study, Oral corticosteroids, Oral prednisone, Papule, Periorbital, Periorbital heliotrope, Periungual, Periungual telangiectasias, Pertinent laboratory findings, Physical examination, Poikiloderma, Prednisone, Primary idiopathic, Prominent periungual telangiectasias, Proximal, Proximal muscle weakness, Proximal muscles, Pulmonary function tests, Rash, Side effects, Skin biopsy, Skin disease, Skin erosions, Skin lesions, Skin rash, Speckled pattern, Spontaneous fibrillations, Telangiectasias, Total resolution, Typical rash, Unremarkable, Upper portion, White woman.
Abstract
Detmatomyositis (DM) is a collagen vascular disease with prominent cutaneous findings. Although the myositis often responds to therapy with corticosteroids and/or immunosuppressives, the cutaneous disease may not respond. Seven patients with cutaneous lesions of DM that had not responded to therapy were treated with hydroxychloroquine in an open study. Three patients had idiopathic DM, one had DM without myositis, one had DM with malignancy, and one had adolescent DM. The response to the addition of hydroxychloroquine was good in all of the patients, and three had total resolution of their skin lesions. In two patients the corticosteroid dosage could be tapered. Therapy with hydroxychloroquine did not appear to have any beneficial effect on the myositis. We conclude that hydroxychloroquine may have a role as an adjuvant to the therapy of patients with cutaneous lesions of DM. (J AM ACAD DERMATOL 10:592-600, 1984.)
Url:
DOI: 10.1016/S0190-9622(84)80263-7
Affiliations:
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Bickers</name></author><author><name sortKey="Hanno, Ruth" sort="Hanno, Ruth" uniqKey="Hanno R" first="Ruth" last="Hanno">Ruth Hanno</name></author><author><name sortKey="Hawkins, Curtis" sort="Hawkins, Curtis" uniqKey="Hawkins C" first="Curtis" last="Hawkins">Curtis Hawkins</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:D837DBF4B04BE2BD217577BBA58F1199BA9ACB5C</idno><date when="1984" year="1984">1984</date><idno type="doi">10.1016/S0190-9622(84)80263-7</idno><idno type="url">https://api.istex.fr/ark:/67375/6H6-GJFS9PQ7-C/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000182</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000182</idno><idno type="wicri:Area/Istex/Curation">000182</idno><idno type="wicri:Area/Istex/Checkpoint">002367</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">002367</idno><idno type="wicri:doubleKey">0190-9622:1984:Woo T:cutaneous:lesions:of</idno><idno type="wicri:Area/Main/Merge">003681</idno><idno type="wicri:Area/Main/Curation">003607</idno><idno type="wicri:Area/Main/Exploration">003607</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Cutaneous lesions of dermatomyositis are improved by hydroxychloroquine</title><author><name sortKey="Woo, Thomas Y" sort="Woo, Thomas Y" uniqKey="Woo T" first="Thomas Y." last="Woo">Thomas Y. Woo</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>Department of Dermatology, University of Michigan Medical School, Ann Arbor</wicri:cityArea></affiliation></author><author><name sortKey="Callen, Jeffrey P" sort="Callen, Jeffrey P" uniqKey="Callen J" first="Jeffrey P." last="Callen">Jeffrey P. Callen</name><affiliation></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Kentucky</region></placeName><wicri:cityArea>Reprint requests to: Dr. Jeffrey P. Callen, 554 Medical Towers South, Louisville</wicri:cityArea></affiliation></author><author><name sortKey="Voorhees, John J" sort="Voorhees, John J" uniqKey="Voorhees J" first="John J." last="Voorhees">John J. Voorhees</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>Department of Dermatology, University of Michigan Medical School, Ann Arbor</wicri:cityArea></affiliation></author><author><name sortKey="Bickers, David R" sort="Bickers, David R" uniqKey="Bickers D" first="David R." last="Bickers">David R. Bickers</name><affiliation><wicri:noCountry code="subField">Cleveland</wicri:noCountry></affiliation></author><author><name sortKey="Hanno, Ruth" sort="Hanno, Ruth" uniqKey="Hanno R" first="Ruth" last="Hanno">Ruth Hanno</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Michigan</region></placeName><wicri:cityArea>Department of Dermatology, Henry Ford Hospital, Detroit</wicri:cityArea></affiliation></author><author><name sortKey="Hawkins, Curtis" sort="Hawkins, Curtis" uniqKey="Hawkins C" first="Curtis" last="Hawkins">Curtis Hawkins</name><affiliation><wicri:noCountry code="subField">Cleveland</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of the American Academy of Dermatology</title><title level="j" type="abbrev">YMJD</title><idno type="ISSN">0190-9622</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1984">1984</date><biblScope unit="volume">10</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="592">592</biblScope><biblScope unit="page" to="600">600</biblScope></imprint><idno type="ISSN">0190-9622</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0190-9622</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acrodermatitis enteropathica</term><term>American academyof dermatology</term><term>Antibody level</term><term>Antimalarial</term><term>Arch dermatol</term><term>Arthralgia</term><term>Barium enema</term><term>Bibasilar rales</term><term>Biopsy</term><term>Black woman</term><term>Chest examination</term><term>Corticosteroid</term><term>Creatinine clearance</term><term>Cutaneous</term><term>Cutaneous disease</term><term>Cutaneous lesions</term><term>Cuticular overgrowth</term><term>Dermatologic evaluation</term><term>Dermatology</term><term>Dermatomyositis</term><term>Direct immunofluorescent biopsy</term><term>Dorsal surfaces</term><term>Erythema</term><term>Facial erythema</term><term>Heliotrope</term><term>Homogeneous pattern</term><term>Hydroxychloroquine</term><term>Insertional irritability</term><term>Intravenous pyelogram</term><term>Joint symptoms</term><term>Laboratory evaluation</term><term>Lesion</term><term>Mayo clinic</term><term>Methotrexate</term><term>Muscle biopsy</term><term>Muscle disease</term><term>Muscle enzymes</term><term>Muscle strength</term><term>Muscle weakness</term><term>Myositis</term><term>Normal limits</term><term>Olmsted syndrome</term><term>Open study</term><term>Oral corticosteroids</term><term>Oral prednisone</term><term>Papule</term><term>Periorbital</term><term>Periorbital heliotrope</term><term>Periungual</term><term>Periungual telangiectasias</term><term>Pertinent laboratory findings</term><term>Physical examination</term><term>Poikiloderma</term><term>Prednisone</term><term>Primary idiopathic</term><term>Prominent periungual telangiectasias</term><term>Proximal</term><term>Proximal muscle weakness</term><term>Proximal muscles</term><term>Pulmonary function tests</term><term>Rash</term><term>Side effects</term><term>Skin biopsy</term><term>Skin disease</term><term>Skin erosions</term><term>Skin lesions</term><term>Skin rash</term><term>Speckled pattern</term><term>Spontaneous fibrillations</term><term>Telangiectasias</term><term>Total resolution</term><term>Typical rash</term><term>Unremarkable</term><term>Upper portion</term><term>White woman</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Detmatomyositis (DM) is a collagen vascular disease with prominent cutaneous findings. Although the myositis often responds to therapy with corticosteroids and/or immunosuppressives, the cutaneous disease may not respond. Seven patients with cutaneous lesions of DM that had not responded to therapy were treated with hydroxychloroquine in an open study. Three patients had idiopathic DM, one had DM without myositis, one had DM with malignancy, and one had adolescent DM. The response to the addition of hydroxychloroquine was good in all of the patients, and three had total resolution of their skin lesions. In two patients the corticosteroid dosage could be tapered. Therapy with hydroxychloroquine did not appear to have any beneficial effect on the myositis. We conclude that hydroxychloroquine may have a role as an adjuvant to the therapy of patients with cutaneous lesions of DM. (J AM ACAD DERMATOL 10:592-600, 1984.)</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Kentucky</li><li>Michigan</li></region></list><tree><noCountry><name sortKey="Bickers, David R" sort="Bickers, David R" uniqKey="Bickers D" first="David R." last="Bickers">David R. Bickers</name><name sortKey="Hawkins, Curtis" sort="Hawkins, Curtis" uniqKey="Hawkins C" first="Curtis" last="Hawkins">Curtis Hawkins</name></noCountry><country name="États-Unis"><region name="Michigan"><name sortKey="Woo, Thomas Y" sort="Woo, Thomas Y" uniqKey="Woo T" first="Thomas Y." last="Woo">Thomas Y. Woo</name></region><name sortKey="Callen, Jeffrey P" sort="Callen, Jeffrey P" uniqKey="Callen J" first="Jeffrey P." last="Callen">Jeffrey P. Callen</name><name sortKey="Hanno, Ruth" sort="Hanno, Ruth" uniqKey="Hanno R" first="Ruth" last="Hanno">Ruth Hanno</name><name sortKey="Voorhees, John J" sort="Voorhees, John J" uniqKey="Voorhees J" first="John J." last="Voorhees">John J. Voorhees</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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